The left part of the viral genome is sufficient for interferon induction by adenovirus type 12. Academic Article uri icon

Overview

abstract

  • Adenovirus type 12 is a potent interferon inducer on chick embryo cells. Incomplete particles induce similar levels of interferon as complete virions, even if they contain only the left 20 per cent of the genome. Empty capsids lacking DNA are not able to induce interferon, suggesting that part of the viral genome is required to trigger the cells to produce interferon.

publication date

  • January 1, 1984

Research

keywords

  • Adenoviridae
  • Adenoviridae Infections
  • Bacterial Proteins
  • Deoxyribonucleases, Type II Site-Specific
  • Interferons

Identity

Scopus Document Identifier

  • 0021323303

Digital Object Identifier (DOI)

  • 10.1007/BF01314302

PubMed ID

  • 6199003

Additional Document Info

volume

  • 79

issue

  • 1-2