Effect of estrogen on the mixed lymphocyte reaction in normal individuals and prostatic cancer patients. Academic Article uri icon

Overview

abstract

  • Lack of initial response or relapse to hormones in advanced prostatic cancer may be due to an adverse effect of estrogen on host immune function. This study investigated the effect of diethylstilbestrol diphosphate (DES-P) on the normal mixed lymphocyte reaction (MLR) and on the MLR in prostatic cancer patients before and during treatment with DES-P. These data showed that the normal MLR was suppressed by high concentrations of estrogen in vitro, but physiologic levels of DES-P were not suppressive. Therapeutic doses of DES-P did not suppress the spontaneous MLR of prostatic cancer patients compared with previous treatment. Estrogens did not significantly impair the immunologic responsiveness of normal individuals or prostatic cancer patients.

publication date

  • January 1, 1982

Research

keywords

  • Diethylstilbestrol
  • Lymphocyte Culture Test, Mixed
  • Lymphocytes
  • Prostatic Neoplasms

Identity

Scopus Document Identifier

  • 0020472066

Digital Object Identifier (DOI)

  • 10.1002/pros.2990030104

PubMed ID

  • 6210901

Additional Document Info

volume

  • 3

issue

  • 1