Metastatic colorectal carcinoma. A prospective randomized trial of Methyl-CCNU, 5-Fluorouracil (5-FU) and vincristine (MOF) versus MOF plus streptozotocin (MOF-Strep). Academic Article uri icon

Overview

abstract

  • A prospective randomized trial evaluated semustine (Methyl CCNU) 5-Fluorouracil (5-FU) and vincristine (MOF) versus MOF plus streptozotocin (MOF-Strep) in 75 patients with advanced, measurable colorectal carcinoma. The complete and partial remission rate with MOF-Strep was significantly better, 34 versus 5% with MOF (P = 0.003). Gastrointestinal toxicity was increased with the addition of streptozotocin. Initial patient characteristics such as age, sex, performance status, time from diagnosis to metastatic disease, site of metastatic disease, and most initial laboratory values were not predictive of response. However, certain initial laboratory values (lactic dehydrogenace and leukocyte count) and one tumor site pulmonary metastases did influence survival regardless of response.

publication date

  • January 1, 1983

Research

keywords

  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Colonic Neoplasms
  • Fluorouracil
  • Nitrosourea Compounds
  • Rectal Neoplasms
  • Semustine
  • Streptozocin
  • Vincristine

Identity

Scopus Document Identifier

  • 0020659797

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19830101)51:1<20::aid-cncr2820510106>3.0.co;2-d

PubMed ID

  • 6217886

Additional Document Info

volume

  • 51

issue

  • 1