Suppression of T cell cytotoxicity by nude mouse spleen cells: reversal by monosaccharides and interleukin 2. Academic Article uri icon

Overview

abstract

  • The effects of monosaccharides on the suppression of cytotoxic T cell generation by spleen cells from nu/nu mice were examined. Suppression of the B6 anti-BALB/c response and the B6 anti-C3H response was reversed by alpha-methyl-D-galactoside (alpha MG) but not other sugars, including beta MG. Suppression was associated with a decrease in the level of IL 2, which suggests competition; this decrease was also reversed by alpha MG.

publication date

  • May 1, 1983

Research

keywords

  • Cytotoxicity, Immunologic
  • Methylgalactosides
  • Methylglycosides
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes, Regulatory

Identity

Scopus Document Identifier

  • 0020633201

PubMed ID

  • 6220084

Additional Document Info

volume

  • 130

issue

  • 5