Soluble factors inhibitory for T-cell-dependent immune responses in patients with the acquired immune deficiency syndrome and its prodromes. Academic Article uri icon

Overview

abstract

  • Supernatants from PBMC obtained from certain patients with AIDS or its prodrome were capable of depressing pokeweed mitogen-driven immunoglobulin production and the proliferative response of T cells to specific antigen. These soluble suppressor factors (SSF) were present in uniquely high concentrations, and were the product of an interaction of T lymphocytes with adherent cells. T-cell independent functions were not modified by soluble suppressor factors. Restoration of immunoglobulin synthesis in SSF-treated cultures was realized by addition of reducing agents such as 2-mercaptoethanol, suggesting inhibitory mechanisms possibly related to that of Con A-induced soluble immune response suppression, and perhaps offering clues to clinically applicable substances capable of modifying such responses. A relationship between SSF-AIDS and a human retrovirus LAV/HTLV III, linked etiologically to AIDS and its prodromes, is suggested by studies of SSF-like substances released by human T-T cell hybridomas derived from LAV+ patients.

publication date

  • January 1, 1984

Research

keywords

  • Acquired Immunodeficiency Syndrome
  • Interleukin-2
  • T-Lymphocytes, Regulatory

Identity

Scopus Document Identifier

  • 0021643853

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.1984.tb37177.x

PubMed ID

  • 6242005

Additional Document Info

volume

  • 437