Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats. Academic Article uri icon

Overview

abstract

  • Five experiments examined the influence of opiate antagonists on both the short-term analgesic reaction resulting 30 min after exposure to inescapable shock and the long-term analgesic reaction resulting after reexposure to shock 24 hr after inescapable shock exposure. Experiment 1 showed that the long-term analgesic reaction could be reduced by administration of naltrexone prior to exposure to inescapable tail shock. Experiment 2 showed that the reduction in the long-term analgesic reaction produced by naltrexone was dose-dependent. Experiment 3 showed that the long-term analgesic reaction could also be reduced by administration of naltrexone prior to reexposure to shock. Experiment 4 showed that the long-term analgesic reaction could be reduced by administration of large dose of naloxone prior to reexposure to shock. Experiment 5 showed that the short-term analgesic reaction was reduced by naltrexone administered prior to inescapable shock. Some implications of these results for the biochemical substrates of both learned helplessness and stress-induced analgesia are discussed.

publication date

  • December 1, 1980

Research

keywords

  • Electroshock
  • Naloxone
  • Naltrexone
  • Nociceptors
  • Receptors, Opioid
  • Stress, Physiological

Identity

Scopus Document Identifier

  • 0019294345

Digital Object Identifier (DOI)

  • 10.1037/h0077743

PubMed ID

  • 6259220

Additional Document Info

volume

  • 94

issue

  • 6