A comparative clinical trial of adriamycin and 5-fluorouracil in advanced prostatic cancer: prognostic factors and response. Academic Article uri icon

Overview

abstract

  • In patients with metastatic hormone-relapsed adenocarcinoma of the prostate, adriamycin was compared to 5-fluorouracil in a randomized trial in 99 patients and adriamycin alone was studied in an open trial in 48 patients. Response to adriamycin was superior as judged by response of measurable disease (25 vs 8%; P less than 0.05) and survival (median 29 vs 24 weeks; Cox analysis, P less than 0.03), but comparable as judged by acid phosphatase response. Ambulatory status and site of metastases influenced rate of response to chemotherapy. Activity level, site of metastases, weight loss, and the symptom of protein aversion were prognostic factors for survival. Hematologic and gastrointestinal toxicity were frequent but were tolerated satisfactorily. Adriamycin therapy may be beneficial in patients with prostatic cancer after hormone therapy.

publication date

  • January 1, 1983

Research

keywords

  • Adenocarcinoma
  • Doxorubicin
  • Fluorouracil
  • Prostatic Neoplasms

Identity

Scopus Document Identifier

  • 0020957960

Digital Object Identifier (DOI)

  • 10.1002/pros.2990040102

PubMed ID

  • 6340081

Additional Document Info

volume

  • 4

issue

  • 1