Antidepressant withdrawal syndromes: evidence supporting the cholinergic overdrive hypothesis. Review uri icon

Overview

abstract

  • The authors present case examples of the various antidepressant withdrawal syndromes. Substantial evidence supports the contention that these syndromes result from cholinergic overdrive; thus, they may have a common pathophysiological basis. Even paradoxical reactions on antidepressant withdrawal, such as mania, are consistent with the cholinergic overdrive hypothesis. If the cholinergic overdrive hypothesis of affective illness. The cholinergic overdrive hypothesis is both of considerable heuristic value and is further testable by the study of the tonic and phasic aspects of sleep and neuroendocrine parameters in the withdrawal state.

publication date

  • June 1, 1983

Research

keywords

  • Antidepressive Agents
  • Parasympathetic Nervous System
  • Substance Withdrawal Syndrome

Identity

Scopus Document Identifier

  • 0020966534

PubMed ID

  • 6348107

Additional Document Info

volume

  • 3

issue

  • 3