Increased susceptibility to infection related to extent of burn injury. Academic Article uri icon

Overview

abstract

  • A model of burn wound sepsis in which the mortality caused by infection was significantly greater after a 60% total body surface area (TBSA) burn than after a 30% TBSA burn was developed in the rat. In rats that sustained a 60% TBSA burn (30% partial plus 30% full thickness), the 30% TBSA partial-thickness burn that was inoculated with Pseudomonas aeruginosa strain 59-1244 developed invasive wound infection (greater 10(5) colony-forming units per gram of tissue). Infection did not develop in rats that had a 30% TBSA partial-thickness burn inoculated, without additional injury. The additional burn in the rats with a 60% TBSA burn seemed to affect the development of infection in the partial-thickness wound and the overall outcome by a mechanism other than by infection of the full-thickness wound itself. Autopsy confirmed that mortality was caused by sepsis.

publication date

  • February 1, 1984

Research

keywords

  • Burns
  • Wound Infection

Identity

Scopus Document Identifier

  • 0021320116

Digital Object Identifier (DOI)

  • 10.1001/archsurg.1984.01390140047008

PubMed ID

  • 6421264

Additional Document Info

volume

  • 119

issue

  • 2