The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats: role of cyclooxygenase inhibition. Academic Article uri icon

Overview

abstract

  • The Dahl salt resistant (DR) rat maintained on a low, 0.4%, or a high 8.0% salt-diet remained normotensive. The bradykinin (BK) induced falls in the systolic (SBP) and diastolic (DBP) were unaffected (P greater than 0.05) by the presence of indomethacin (5 mg/kg). Indomethacin, however, caused a substantial (P less than 0.001) reduction in the duration of the hypotensive action of bradykinin. It is speculated that the indomethacin effects result from an inhibition of the cyclooxygenase system in DR rats.

publication date

  • April 1, 1984

Research

keywords

  • Blood Pressure
  • Bradykinin
  • Cyclooxygenase Inhibitors
  • Indomethacin

Identity

Scopus Document Identifier

  • 0021356349

Digital Object Identifier (DOI)

  • 10.1016/0262-1746(84)90031-3

PubMed ID

  • 6427790

Additional Document Info

volume

  • 14

issue

  • 1