Dose-rate effect between 1 and 10 Gy/min in mammalian cell culture. Academic Article uri icon

Overview

abstract

  • A dose-rate effect is observed between 1 and 10 Gy/min for cultured Chinese hamster V-79 fibroblast cells irradiated under pO2 levels of less than 10 ppm, 100 ppm, 300 ppm and 21%. The dose for a cellular surviving fraction of 0.1% increases by 10-15% as the dose rate is changed from 10 to 1 Gy/min. This observed dose-rate effect is consistent with the repair of sublethal damage taking place during the radiation delivery. A related finding is that acute hypoxia in cell culture does not inhibit sublethal damage repair.

publication date

  • August 1, 1984

Research

keywords

  • Cell Survival
  • Dose-Response Relationship, Radiation

Identity

Scopus Document Identifier

  • 0021175093

Digital Object Identifier (DOI)

  • 10.1259/0007-1285-57-680-723

PubMed ID

  • 6466946

Additional Document Info

volume

  • 57

issue

  • 680