Fluorometric measurement of tin-protoporphyrin in biological samples. Academic Article uri icon

Overview

abstract

  • Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, can suppress neonatal and other forms of hyperbilirubinemia in laboratory animals, and represents a potential new approach to the treatment of neonatal jaundice in humans. In order to study the disposition of Sn-protoporphyrin in vivo we have developed a sensitive fluorometric method for the quantitation of this metalloporphyrin in biological samples. The method is sensitive to concentrations as low as 0.01 nmol/ml, and is specific for Sn-protoporphyrin even in the presence of other porphyrins such as protoporphyrin.

publication date

  • August 15, 1984

Research

keywords

  • Metalloporphyrins
  • Porphyrins
  • Protoporphyrins

Identity

Scopus Document Identifier

  • 0021163824

Digital Object Identifier (DOI)

  • 10.1016/0003-2697(84)90448-2

PubMed ID

  • 6496929

Additional Document Info

volume

  • 141

issue

  • 1