Narcolepsy: cholinergic receptor changes in an animal model. Academic Article uri icon

Overview

abstract

  • An inbred colony of narcoleptic doberman pinschers has been analyzed for muscarinic receptor levels in 19 discrete brain regions. In comparison to age-matched controls, receptors were generally elevated in the brainstem and reduced in forebrain areas. No changes in receptor binding affinity were detected. The increased receptor levels found in the brainstem suggest that cholinoceptive neurons in this region are hypersensitive and may be involved in the initiation of cataplexy and other aspects of the narcolepsy syndrome.

publication date

  • May 7, 1984

Research

keywords

  • Narcolepsy
  • Receptors, Muscarinic

Identity

Scopus Document Identifier

  • 0021142312

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(84)90675-1

PubMed ID

  • 6539848

Additional Document Info

volume

  • 34

issue

  • 19