Brain Ia antigens have a bone marrow origin. Academic Article uri icon

Overview

abstract

  • Our results, using radiation-induced bone marrow chimeras, demonstrate that the Ia antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of Ia in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

publication date

  • January 1, 1983

Research

keywords

  • Bone Marrow
  • Brain
  • Histocompatibility Antigens Class II

Identity

Scopus Document Identifier

  • 0020623102

Digital Object Identifier (DOI)

  • 10.1007/BF00364413

PubMed ID

  • 6572615

Additional Document Info

volume

  • 17

issue

  • 3