Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes. uri icon

Overview

abstract

  • A patient with L3 leukemia is reported whose leukemic cells were characterized cytogenetically by a duplication of the long arm segment 1q25 leads to q42, trisomy for chromosome 7, t(8;22)(q24;q11), and two 14q+ chromosomes. Immunologic marker analysis revealed the leukemic cells to be of the non-T, non-B ("null") type. This observation, when considered in conjunction with a previous report of heterogeneity in cell lineages of L3 leukemias, raises the possibility of some lymphoid neoplasms arising in stem cells.

publication date

  • September 1, 1983

Research

keywords

  • Chromosome Aberrations
  • Chromosome Disorders
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 21-22 and Y
  • Chromosomes, Human, 6-12 and X
  • Leukemia, Lymphoid
  • Lymphocytes, Null
  • Translocation, Genetic

Identity

Scopus Document Identifier

  • 0020624471

Digital Object Identifier (DOI)

  • 10.1016/0165-4608(83)90110-3

PubMed ID

  • 6576853

Additional Document Info

volume

  • 10

issue

  • 1