Human leukocyte (alpha) interferon in metastatic malignant melanoma: the American Cancer Society phase II trial. Academic Article uri icon

Overview

abstract

  • Forty-four evaluable patients with metastatic malignant melanoma confined to the skin, subcutaneous tissues, lymph nodes, and/or lung were randomly assigned to receive either 1 X 10(6), 3 X 10(6), or 9 X 10(6) units of partially purified human leukocyte (alpha) interferon by daily im injection for 42 days. One patient achieved a partial response, two had minor responses, and three others had mixed responses. The only partial response was observed at the lowest dose of interferon. Toxicity increased in frequency and intensity with increasing interferon dose. This preparation of interferon at the doses, route, and schedule used appears to have little efficacy in metastatic malignant melanoma.

publication date

  • May 1, 1984

Research

keywords

  • Interferon Type I
  • Melanoma

Identity

Scopus Document Identifier

  • 0021258148

PubMed ID

  • 6722830

Additional Document Info

volume

  • 68

issue

  • 5