Glucose turnover and gluconeogenesis during hypocaloric glucose infusion in tumor-bearing F344 male rats. Academic Article uri icon

Overview

abstract

  • Glucose turnover ([3(3)H]glucose) and gluconeogenesis from alanine ([U-14C]alanine) were measured in non-tumor bearing (NTB) and tumor-bearing (TB) inbred F344 male rats during starvation and in response to graded levels of glucose infusion. All groups demonstrated a glucose turnover appropriate to the prevailing steady-state plasma glucose level. Whereas NTB animals exhibited maximal suppression of gluconeogenesis from alanine at infusion rates of 0.39 mg/100 g total body weight/minute, TB animals suppressed alanine-to-glucose conversion only at a glucose infusion rate of 0.71 mg/100 g total body weight/minute. Glucose clearance was consistently higher in TB groups but did not change in either NTB or TB groups during infusion. Blood lactate levels increased in response to glucose infusion only in TB animals. These results suggested that starved TB animals obligately utilized more glucose than did NTB controls but were able to adjust turnover appropriately to plasma glucose levels. However, gluconeogenesis was suppressed only at higher glucose infusion rates in TB rats compared to NTB animals.

publication date

  • February 1, 1980

Research

keywords

  • Blood Glucose
  • Fibrosarcoma
  • Gluconeogenesis
  • Glucose

Identity

Scopus Document Identifier

  • 0018842050

Digital Object Identifier (DOI)

  • 10.1093/jnci/64.2.291

PubMed ID

  • 6928221

Additional Document Info

volume

  • 64

issue

  • 2