Positron imaging feasibility studies: selective tumor concentration of 3H-thymidine, 3H-uridine, and 14C-2-deoxyglucose. Academic Article uri icon

Overview

abstract

  • The potential usefulness of substrates for glycolysis and nucleic acid synthesis as tumor imaging agents was compared to that of 67Ga-citrate. In separate experiments, 3H-thymidine, 3H-uridine, 14C-2-deoxyglucose, and 67Ga-citrate were injected intraveneously into BALB/c mice with solid subcutaneous EMT-6 sarcomas. For the 3H- and 14C-labeled substrates, absolute uptakes in tumor and tumor-to-blood ratios were as high 1 hour after injection as the comparable maximum values achieved for 67Ga-citrate after 48 hours. These studies suggest that positron-labeled analogues of thymidine, uridine, and 2-deoxyglucose should be useful radiopharmaceuticals for tumor imaging by positron-emission tomography.

publication date

  • March 1, 1980

Research

keywords

  • Carbon Radioisotopes
  • Neoplasms, Experimental
  • Tomography, Emission-Computed
  • Tritium

Identity

Scopus Document Identifier

  • 0018907189

Digital Object Identifier (DOI)

  • 10.1148/radiology.134.3.6965545

PubMed ID

  • 6965545

Additional Document Info

volume

  • 134

issue

  • 3