Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors. Academic Article uri icon

Overview

abstract

  • The effect of acute phenylethanolamine-N-methyltransferase (PNMT) inhibition on rat brain catecholamine concentrations was studied. All PNMT inhibitors tested were effective in depleting hypothalamic and brain stem epinephrine. Norepinephrine concentrations were unaffected; however, dopamine levels were increased in all areas studied. While several possible explanations are offered for this phenomenon, the mechanism is not yet understood.

publication date

  • October 20, 1980

Research

keywords

  • Brain Stem
  • Catecholamines
  • Hypothalamus
  • Phenylethanolamine N-Methyltransferase
  • Rats

Identity

Scopus Document Identifier

  • 0019179212

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(80)90235-9

PubMed ID

  • 7052550

Additional Document Info

volume

  • 20

issue

  • 1