Effects of estrogen administration on serum testosterone in Copenhagen rats. Academic Article uri icon

Overview

abstract

  • In order to develop a standard experimental method of exogenous therapy in the Copenhagen rat, several treatment regimens were evaluated to determine their effect on the serum testosterone. Diethylstilbestrol diphosphate (DES-P) was administered either continuously in the drinking water or as a single intraperitoneal injection. Oral low-dose estrogen (0.4-1.6 microgram/ml) yielded reliable suppression of serum testosterone to castrate levels. A single intraperitoneal injection of 0.5 mg DES-P caused prompt suppression of serum testosterone with return to normal levels two weeks later.

publication date

  • January 1, 1982

Research

keywords

  • Antineoplastic Agents
  • Diethylstilbestrol
  • Rats, Inbred Strains
  • Testosterone

Identity

Scopus Document Identifier

  • 0020317347

Digital Object Identifier (DOI)

  • 10.1002/pros.2990030305

PubMed ID

  • 7100003

Additional Document Info

volume

  • 3

issue

  • 3