Amphotericin B as a urologic irrigant in the management of noninvasive candiduria. Academic Article uri icon

Overview

abstract

  • High urinary colony counts of Candida may develop in patients with prolonged indwelling bladder catheters, multiple antibiotic usage and compromised host resistance. Serum candidal antibody titers may differentiate candidal colonization or early infection from invasive or disseminated infection. The persistence of marked candiduria in the absence of elevated antibody titers or other manifestations of disseminated infection presents a therapeutic dilemma to the urologist. Should the patient be treated with systemic therapy, that is flucytosine or intravenous amphotericin B, or should he be observed until the signs of systemic or renal infection develop? Amphotericin B may be used as a urological irrigant in the management of noninvasive urinary fungal infection. Of 40 patients with persistent candiduria treated with daily irrigations of amphotericin B via a 3-way indwelling urethral catheter or urethral catheter and suprapubic tube for an average of 6 days 37 (92.5 per cent) demonstrated marked reduction or elimination of the candiduria. None of the patients had an adverse reaction. Amphotericin B also has been used as a urological adjuvant to surgical treatment of candidal infection of the kidney and upper tract. It also has a role in the treatment in candidal urethritis. We believe that the timely use of amphotericin B irrigations may prevent the development of disseminated candidal infection.

publication date

  • July 1, 1982

Research

keywords

  • Amphotericin B
  • Candidiasis
  • Therapeutic Irrigation
  • Urinary Tract Infections

Identity

Scopus Document Identifier

  • 0019981870

Digital Object Identifier (DOI)

  • 10.1016/s0022-5347(17)52765-2

PubMed ID

  • 7109077

Additional Document Info

volume

  • 128

issue

  • 1