[Effect of destruction of the paraventricular and mediobasal sections of the hypothalamus on the course of pain shock in rabbits].

Overview

Experiments were made on conscious rabbits with pain shock induced by electric stimulation of the sciatic nerve. Destruction of the paraventricular hypothalamus (primarily of the dorsomedial and paraventricular hypothalamus (primarily of the dorsomedial and paraventricular nuclei) was found to lead, in the presence of shock development, to AP rise, normalization of the heart and respiration rates within 5 to 10 minutes after the destruction. Three out of the 6 animals survived. At the same time destruction of the mediobasal hypothalamus (the arcuate and ventromedial nuclei) did not entail any marked changes in the cardiovascular system. Further progress of shock and the time of the death of all the animals of the latter group did not significantly differ from those seen in the sham-operated animals' group where all animals also died.