Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis. Academic Article uri icon

Overview

abstract

  • Enhanced synthesis of prostaglandin (PG) E by explanted fetal rat bones was initiated by lymphocyte-conditioned media but not by physiological levels of parathyroid hormone. Rapid release of PGE from bone occurred only when the lymphokine was present. Synthesis of PGE preceded and was necessary for the bone resorption caused by the lymphokine preparation. Local production of prostaglandins in response to inflammatory cell or tumor-derived factors may in part be responsible for the localized bone loss that occurs in certain pathological states.

publication date

  • August 1, 1981

Research

keywords

  • Bone Resorption
  • Lymphokines
  • Prostaglandins E

Identity

PubMed Central ID

  • PMC2186425

Scopus Document Identifier

  • 0019467276

Digital Object Identifier (DOI)

  • 10.1084/jem.154.2.529

PubMed ID

  • 7264565

Additional Document Info

volume

  • 154

issue

  • 2