Time dependent effects of adriamycin and x-ray therapy on wound healing in the rat. Academic Article uri icon

Overview

abstract

  • Wound healing as measured by wound breaking strength (WBS) was studied in male Fischer rats. Animals were wounded (day 0) and treated with Adriamycin (ADR), x-ray therapy (XRT), or the combination of ADR + XRT. Treatments were either on day -7,0 or +7. Animals were killed on days +14 and +21, and excised wounds were subjected to uniaxial extension and the recording of WBS (grams), hydroxy-proline assay, and collagen fiber diameter measurements. Day 0 treatment yielded WBS averaging 46% (ADR), 41% (XRT), and 26% (ADR + XRT) of control by 21 days. Newly synthesized hydroxyproline (scar collagen) values of day 0 treated animals were 47% (ADR), 66% (XRT), and 39% (ADR + XRT) of control at 21 days. Day -7 treatment yielded similar WBS values. Withholding single agent or combined treatment until day +7 yielded WBS values comparable to control at 14 or 21 days. In this model, day 0 treatment with ADR, XRT, or ADR + XRT impaired WBS most significantly. This was supported by a diminution in newly synthesized hydroxyproline and load extension curve analysis.

publication date

  • June 1, 1980

Research

keywords

  • Doxorubicin
  • Wound Healing

Identity

Scopus Document Identifier

  • 0018886553

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19800601)45:11<2805::aid-cncr2820451115>3.0.co;2-#

PubMed ID

  • 7379011

Additional Document Info

volume

  • 45

issue

  • 11