Interaction of age and sex in sympathetic axon ingrowth into the hippocampus following septal afferent damage. Academic Article uri icon

Overview

abstract

  • Damage to the medial septal nucleus or to the fimbria/fornix in the adult rat elicits sprouting of vascular sympathetic fibers into the deafferented regions of the hippocampal formation. The following study examines the effects of developmental stage and sex on this sprouting phenomenon using both fluorescence histochemistry and high affinity uptake of noradrenaline. We find that (1) the sprouting, which is reduced in adult and juvenile males relative to females, is equivalent in the two sexes after transections at postnatal day 3, and (2) the period of maximum ingrowth is sexually regulated, occurring near postnatal day 3 in the male and postnatal day 13 in the female.

publication date

  • January 1, 1980

Research

keywords

  • Aging
  • Hippocampus
  • Nerve Regeneration
  • Sympathetic Nervous System

Identity

Scopus Document Identifier

  • 0019150281

Digital Object Identifier (DOI)

  • 10.1007/BF00305342

PubMed ID

  • 7469040

Additional Document Info

volume

  • 161

issue

  • 2