Somatically mutated member of the human V lambda VIII gene family encodes anti-myelin-associated glycoprotein (MAG) activity. Academic Article uri icon

Overview

abstract

  • A highly conserved small family of human V lambda genes was identified by DNA homology to a V lambda gene isolated from a patient with demyelinating peripheral neuropathy, and which encodes an autoantibody with anti-MAG activity. Comparison of the genes indicates that the patient V lambda gene was derived from one of the germline genes. Together with published analyses of other anti-MAG IgM antibodies, which also appear to be mutated in comparison to known germline V genes, these results suggest that development of these pathogenic antibodies may reflect an antigen-driven, T cell-dependent process.

publication date

  • April 1, 1994

Research

keywords

  • Autoantibodies
  • Immunoglobulin Light Chains
  • Immunoglobulin Variable Region
  • Immunoglobulin lambda-Chains
  • Mutation
  • Myelin Proteins

Identity

Scopus Document Identifier

  • 0028289147

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(94)90127-9

PubMed ID

  • 7512577

Additional Document Info

volume

  • 51

issue

  • 1