Aluminium reduces glutamate-activated currents of rat hippocampal neurones. Academic Article uri icon

Overview

abstract

  • The actions of aluminum on glutamate-activated currents of acutely isolated hippocampal neurones were investigated. N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and glutamate mediated currents were reduced by 50% in the presence of 1.4 micrograms ml-1 aluminium. Higher concentrations (> or = 2.7 micrograms ml-1) inhibited all currents completely and irreversibly. Additionally, successive application of agonists in the presence of 2.7 micrograms ml-1 aluminium resulted in non-specific membrane currents followed by the loss of the seal resistance. Application of aluminium per se had no influence on resting membrane current or voltage-activated sodium currents. The estimation of the concentration-response relationship of the action of aluminium on NMDA-activated currents revealed a threshold concentration < 0.27 micrograms ml-1. Our data indicate that glutamate receptors are putative sites of action in aluminium neurotoxicity.

publication date

  • November 21, 1994

Research

keywords

  • Aluminum
  • Glutamic Acid
  • Hippocampus
  • Neurons

Identity

Scopus Document Identifier

  • 0028126616

Digital Object Identifier (DOI)

  • 10.1097/00001756-199411000-00030

PubMed ID

  • 7533557

Additional Document Info

volume

  • 5

issue

  • 17