Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice. Academic Article uri icon

Overview

abstract

  • Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.

publication date

  • December 1, 1994

Research

keywords

  • Arteriosclerosis
  • Diet, Atherogenic
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Recombination, Genetic

Identity

Scopus Document Identifier

  • 0028618173

Digital Object Identifier (DOI)

  • 10.1007/BF00566060

PubMed ID

  • 7748156

Additional Document Info

volume

  • 32

issue

  • 11-12