The relative biological effectiveness of I-125 and Pd-103. Academic Article uri icon

Overview

abstract

  • PURPOSE: To determine the relative biological effectiveness (RBE) of I-125 and Pd-103 relative to Co-60. METHODS AND MATERIALS: A cell line REC:ras, derived from rat embryo cells, was used. Cells in exponential or plateau phase were irradiated at dose rates of about 0.07 Gy/h and 0.14 Gy/h. To circumvent the interface effect, cells were grown and irradiated on membranes made of cellulose acetate, which has an effective Z of 7.5. I-125 and Pd-103 seeds were placed in a custom designed template that yielded a homogeneous dose distribution in the plane of the cell culture. The dose rates of irradiation were measured by calibrated thermoluminescence dosimetry (TLD) chips. RESULTS AND CONCLUSIONS: Our measurements yielded an RBE of about 1.4 for I-125 at dose rates of about 0.07 Gy/h, and an RBE of about 1.9 for Pd-103 at dose rates of about 0.07 Gy/h and 0.14 Gy/h. The RBE of I-125 is similar to those measured by other investigators, the RBE for Pd-103 is being reported for the first time.

publication date

  • May 15, 1995

Research

keywords

  • Iodine Radioisotopes
  • Palladium
  • Radioisotopes

Identity

Scopus Document Identifier

  • 0029057911

Digital Object Identifier (DOI)

  • 10.1016/0360-3016(95)00530-C

PubMed ID

  • 7751179

Additional Document Info

volume

  • 32

issue

  • 2