Energy status parameters, hypoxia fraction and radiocurability across tumor types. Academic Article uri icon

Overview

abstract

  • Under full nutrient in vitro conditions, the cellular adenylate energy charge of six different rodent and human tumor cell types was identical, i.e., 0.94 +/- 0.01, suggesting the potential utility of this parameter as a cell (and tissue) independent marker of nutrient deprivation and hypoxia, across tumor types. The adenylate energy charge values of tumors, arising from these cells, was reduced and variable ranging from 0.72 to 0.91 for the various tumor types. However, neither the tumor adenylate energy charge, NTP/Pi, nor PCr/Pi ratios correlated with the radiobiologic hypoxic cell fractions across tumor types. The reduced adenylate energy charge in vivo suggests varying degrees of nutrient deprivation in the different tumor types, however, factors other than or in addition to hypoxia likely contribute to tumor energy status.

publication date

  • January 1, 1995

Research

keywords

  • Adenine Nucleotides
  • Energy Metabolism
  • Neoplasms
  • Neoplasms, Experimental

Identity

Scopus Document Identifier

  • 0029074927

Digital Object Identifier (DOI)

  • 10.3109/02841869509093985

PubMed ID

  • 7779419

Additional Document Info

volume

  • 34

issue

  • 3