Carcinoma of the esophagus. Prognostic significance of histologic type. Academic Article uri icon

Overview

abstract

  • Previous investigators have reported that in patients with esophageal carcinoma tumor cell type affects prognosis. A retrospective analysis of 258 patients, from 1985 to 1991, undergoing curative esophagogastrectomy for adenocarcinoma (n = 134) or squamous cell carcinoma (n = 124) was performed to test the hypothesis that histologic cell type is an independent prognostic factor and to identify other predictors of survival after resection. The actuarial overall survival (p = 0.16) and disease-specific survival (p = 0.68) were similar for adenocarcinoma (median overall survival = 27 months) and squamous cell carcinoma (median overall survival = 22 months). Univariate analysis identified T stage, N stage, number of diseased nodes, tumor differentiation, tumor site, and blood transfusions as significant (p < 0.05) variables in predicting overall survival. The presence of Barrett's esophagus was not predictive of survival. Multivariate analysis demonstrated that T stage (p = 0.006), N stage (p = 0.01), and number of diseased lymph nodes (p = 0.03) were independent predictors of overall survival. This analysis demonstrated that histologic type is not an independent variable for overall survival in patients undergoing curative esophagogastrectomy for carcinoma of the esophagus and gastroesophageal junction. Outcome is most strongly influenced by extent of disease defined by T and N stage.

publication date

  • January 1, 1995

Research

keywords

  • Adenocarcinoma
  • Carcinoma, Squamous Cell
  • Esophageal Neoplasms

Identity

Scopus Document Identifier

  • 0028797425

Digital Object Identifier (DOI)

  • 10.1016/S0022-5223(95)70428-0

PubMed ID

  • 7815789

Additional Document Info

volume

  • 109

issue

  • 1