IgE-mediated cardiac hypersensitivity reactions. An experimental model. Academic Article uri icon

Overview

abstract

  • To investigate the involvement of the heart in acute allergic reactions in a system immunologically analogous to that of humans, a model of cardiac anaphylaxis mediated by IgE antibodies was developed in the guinea pig. Hearts obtained from guinea pigs, passively sensitized with homologous antidinitrophenyl IgE antibodies, were perfused and challenged in vitro with antigen. Challenge resulted in sinus and ventricular tachycardia, atrioventricular conduction block and substantial histamine release. The results demonstrate that IgE antibodies can sensitize the heart and that the severity of cardiac dysfunction, which follows challenge with specific antigen, directly correlates with the magnitude of histamine released. Since myocardial ischemia and similar arrhythmias occur during immediate hypersensitivity reactions in humans, this experimental model will be helpful in the investigation of cardiac involvement in acute allergic reactions.

publication date

  • January 1, 1978

Research

keywords

  • Anaphylaxis
  • Heart
  • Immunoglobulin E

Identity

Scopus Document Identifier

  • 0018133509

Digital Object Identifier (DOI)

  • 10.1159/000232148

PubMed ID

  • 79558

Additional Document Info

volume

  • 57

issue

  • 6