Acute impairment of coronary blood flow by dynamic cardiomyoplasty. Academic Article uri icon

Overview

abstract

  • The aim of this study was to quantify the effects of three different configurations of cardiomyoplasty on coronary blood flow in an acute dog model. Thirteen dogs had both latissimus dorsi muscles harvested and transposed to the chest. Coronary blood flow was measured using Doppler cuff probes on the left anterior descending and circumflex coronary arteries during each of three cardiomyoplasty configurations: left posterior, right anterior, and double. Multiple beat measures were made of systolic and diastolic flow during a control protocol and a subsequent protocol with the muscle(s) paced. Significant flow reductions during pacing were observed in the left anterior descending coronary artery during left posterior (17%, p = 0.003), right anterior (29%, p < 0.0001), and double (35%, p = 0.0001) myoplasty. Similar reductions occurred in the circumflex artery (14%, p = 0.0009; 20%, p = 0.001; 27%, p = 0.0053). The net flow over an entire pacing cycle also was reduced significantly: left anterior descending artery (11%, p = 0.0035; 23%, p = 0.0001; 23%, p = 0.0047) and circumflex artery (10%, p = 0.0025; 17%, p = 0.0018; 21%, p = 0.0091). Thus, in the acute setting cardiomyoplasty depresses coronary blood flow. A chronic setting will be needed to determine the ultimate significance of these results.

publication date

  • July 1, 1994

Research

keywords

  • Assisted Circulation
  • Coronary Circulation
  • Electric Stimulation Therapy
  • Muscles
  • Myocardial Ischemia
  • Surgical Flaps

Identity

Scopus Document Identifier

  • 0028059306

Digital Object Identifier (DOI)

  • 10.1016/0003-4975(94)91084-7

PubMed ID

  • 8037509

Additional Document Info

volume

  • 58

issue

  • 1