Allogeneic bone marrow transplantation for leukemia following piperazinedione and fractionated total body irradiation. Academic Article uri icon

Overview

abstract

  • Between 1980 and 1988, 126 patients with leukemia were treated with piperazinedione and fractionated total body irradiation (TBI) followed by allogeneic bone marrow transplantation from HLA matched siblings. Sixty-one patients had acute myelogenous leukemia, 46 acute lymphoblastic leukemia, and 19 chronic myelogenous leukemia. Patients with acute leukemia in first complete remission were transplanted only if perceived to have a low probability of remaining in remission with conventional therapy. The toxicity from the preparative regimen was similar to that of cyclophosphamide and TBI except that none of the patients in the study had hemorrhagic cystitis or veno-occlusive disease. After a median follow up of 114 months, 29 patients (23%) are still alive without relapse. The survival of patients with acute myelogenous or lymphoblastic leukemia transplanted in their first remission were 35% and 43%, respectively. The survival of patients transplanted in their first chronic phase of chronic myelogenous leukemia was 60%. The results of this preparative regimen are comparable to those of cyclophosphamide and TBI.

authors

  • Berman, Ellin
  • Dimopoulos, M A
  • Yau, J C
  • Huan, S D
  • Jagannath, Sundar
  • Spitzer, Gary
  • Spinolo, J A
  • Zagars, G K
  • LeMaistre, C F
  • Dicke, K A
  • Zander, A R

publication date

  • June 1, 1994

Research

keywords

  • Antibiotics, Antineoplastic
  • Bone Marrow Transplantation
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid, Acute
  • Piperazines
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

Identity

Scopus Document Identifier

  • 0028298342

Digital Object Identifier (DOI)

  • 10.1002/ajh.2830460205

PubMed ID

  • 8172200

Additional Document Info

volume

  • 46

issue

  • 2