Extracellular pH modulates aluminium-blockade of mammalian voltage-activated calcium channel currents. Academic Article uri icon

Overview

abstract

  • The pH-dependence of aluminium (Al) blockade of voltage activated calcium channels (VACCs) was investigated. Using cultures of rat dorsal root ganglion (DRG) neurones, whole-cell patch-clamp experiments were performed. Various concentrations of Al were extracellularly applied within solutions of different pH-values. The block of VACC currents was highly pH-dependent. At pH 7.3-7.8, the concentration-response curve shifted slightly to higher concentrations, whereas at pH 6.4-6.9 a pronounced shift to lower concentrations was observed. This effect could be due to changes of the chemical equilibria of the different Al species or to altered properties of the VACCs. Thus, pH-shifts may influence the interactions of Al with VACCs making them more susceptible to the effects of Al and therefore contribute to its toxicity.

publication date

  • September 10, 1993

Research

keywords

  • Aluminum
  • Calcium Channel Blockers
  • Extracellular Space
  • Neurons

Identity

Scopus Document Identifier

  • 0027421808

Digital Object Identifier (DOI)

  • 10.1097/00001756-199309000-00010

PubMed ID

  • 8219023

Additional Document Info

volume

  • 4

issue

  • 11