Acquired ichthyosis in concomitant HIV-1 and HTLV-II infection: a new association with intravenous drug abuse. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Papulosquamous eruptions are common in HIV-1-infected patients. Acquired ichthyosis may occur after profound T-cell depletion. Intravenous drug users infected with HIV-1 can be coinfected with human lymphotropic virus II (HTLV-II). OBJECTIVE: We examined the relation between acquired ichthyosis and concomitant infection with HIV-1 and HTLV-II in intravenous drug users. METHODS: We examined 184 male and female HIV-1-positive intravenous drug users for acquired ichthyosis. Enzyme-linked immunosorbent assay was used to screen these patients for antibody to HTLV-I/II. Western blot, viral isolation, and the polymerase chain reaction were used to confirm that serologic responses were from HTLV-II and not HTLV-I. RESULTS: Acquired ichthyosis occurred in 6.3% of white, 16.4% of Hispanic, and 21.7% of black patients. It occurred only after profound helper T-cell depletion, in association with increasing age, and with concomitant infection with HTLV-II (22.2% vs. 6.8% in HIV-1 singly infected patients [p < 0.038]). CONCLUSION: Acquired ichthyosis may be a marker of concomitant infection with HIV-1 and HTLV-II in intravenous drug users and occurs after profound helper T-cell depletion.

publication date

  • November 1, 1993

Research

keywords

  • Acquired Immunodeficiency Syndrome
  • HIV-1
  • HTLV-II Infections
  • Human T-lymphotropic virus 1
  • Human T-lymphotropic virus 2
  • Ichthyosis
  • Substance Abuse, Intravenous

Identity

Scopus Document Identifier

  • 0027444680

Digital Object Identifier (DOI)

  • 10.1016/0190-9622(93)70234-k

PubMed ID

  • 8227542

Additional Document Info

volume

  • 29

issue

  • 5 Pt 1