Do GM1 antibodies induce demyelination? Academic Article uri icon

Overview

abstract

  • We review clinical, neurophysiological, immunological, and experimental data concerning multifocal motor neuropathy (MMN), a newly recognized disorder that mimics MND. It is separated from MND by the presence of multifocal conduction block (CB) demonstrated electrophysiologically, and in some instances by the association of high titers of GM1 antibodies. The possible immunopathogenetic effect of GM1 antibodies is discussed. However, 70% of patients with MMNCB do not have elevated titers of GM1 antibodies, but may respond nevertheless to immunosuppressive treatment. Thus, so far unrecognized antibodies may react against some other epitopes in the paranodal region than those attacked by GM1 antibodies to cause CB.

publication date

  • January 1, 1994

Research

keywords

  • Antibodies
  • Demyelinating Diseases
  • G(M1) Ganglioside
  • Nervous System Diseases

Identity

Scopus Document Identifier

  • 0028181628

Digital Object Identifier (DOI)

  • 10.1002/mus.880170116

PubMed ID

  • 8264688

Additional Document Info

volume

  • 17

issue

  • 1