Fractionated high-dose rate brachytherapy for intracranial gliomas.

Overview

PURPOSE: To develop a catheter system for fractionated high-dose rate (HDR) brachytherapy for intracranial gliomas. METHODS AND MATERIALS: The catheter system for stereotactic placement as well as delivery of the high-dose rate iridium-192 source wire is described. The force of the impulse wave from the source wire entering brain equivalent material was measured. Dose volume histograms for the first 5 patients treated are presented. RESULTS: The catheter system was found to be satisfactory. The maximum force of the impulse wave was less than 1 acceleration of gravity (which is safe). The patients tolerated the treatment well with no significant problems related to the catheters being left in situ for up to 14 days. CONCLUSION: Based on this pilot experience a phase I dose escalating and morbidity study has been initiated.