Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Although patients with neuroendocrine tumors typically exhibit an indolent clinical course, the pace of disease accelerates and the prognosis deteriorates once objective progression of disease begins. Thirty-four patients with advanced neuroendocrine tumors were treated with octreotide as antineoplastic therapy. This treatment was begun only after documentation of clear objective progression of disease. METHODS: A Phase II trial was performed at a tertiary comprehensive cancer center. RESULTS: The median survival for this patient population from the start of octreotide therapy has not been reached, with a median follow-up of 29 months (range, 1-47 months). No major objective tumor regressions were seen. Seventeen patients (50%) experienced a computed tomography-documented stabilization of disease that was maintainable for a minimum of 2 months (median, 5 months; range, 0-27 months). Of the 34 patients, 20 patients received octreotide as their first antineoplastic therapy. The median survival for these 20 patients has not been reached, with a median follow-up also of 29 months (range, 12-41 months). CONCLUSIONS: Octreotide may influence the natural history of neuroendocrine tumors. The survival in patients treated with octreotide, as measured from the time of progression of disease, compares favorably with that of historical controls. Proof of a survival advantage for patients treated with octreotide would require a multicenter, randomized trial.

publication date

  • July 1, 1993

Research

keywords

  • Adenoma, Islet Cell
  • Carcinoid Tumor
  • Octreotide
  • Pancreatic Neoplasms

Identity

Scopus Document Identifier

  • 0027198659

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19930701)72:1<244::aid-cncr2820720143>3.0.co;2-q

PubMed ID

  • 8389666

Additional Document Info

volume

  • 72

issue

  • 1