Increased chemotactic activity of peritoneal fluid in patients with endometriosis. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: Our purpose was to investigate the ability of the peritoneal fluid of patients with endometriosis to induce chemotaxis of neutrophils and macrophages. STUDY DESIGN: Peritoneal fluid samples of patients with endometriosis (n = 20), normal fertile controls (n = 12), or patients with medical suppression (n = 8) were evaluated for chemotactic activity. Results of chemotactic activity were analyzed by analysis of variance. RESULTS: Peritoneal fluid of patients with endometriosis demonstrated a significantly higher chemotactic activity than that of patients without endometriosis or with medical suppression. Patients who had received medical treatment had the lowest chemotactic activity. (p < 0.001 for endometriosis vs control or treatment patients, p = 0.005 for control group vs treatment group). CONCLUSIONS: Patients with endometriosis have a higher chemotactic activity in their peritoneal fluid; prior medical treatment significantly reduces this activity. This chemotactic factor has an estimated weight of 20 kd. The nature and source of this chemotactic factor remains to be determined.

publication date

  • February 1, 1993

Research

keywords

  • Ascitic Fluid
  • Chemotaxis
  • Endometriosis

Identity

Scopus Document Identifier

  • 0027461566

Digital Object Identifier (DOI)

  • 10.1016/0002-9378(93)90500-i

PubMed ID

  • 8438934

Additional Document Info

volume

  • 168

issue

  • 2