N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma). Academic Article uri icon

Overview

abstract

  • Using nucleic acid analysis and in situ hybridization we have demonstrated N-myc amplification and expression in two children with a localized (stages I and II) stroma-rich neuroblastoma (NB) (ganglioneuroblastoma). The phenomenon was observed in both undifferentiated and mature ganglion-like cells. The two children are alive and disease-free without any treatment after 16 and 17 months. These observations suggest that morphologic differentiation in NB in vivo is not necessarily followed by a decrease in N-myc expression. Moreover, N-myc amplification does not represent an adverse prognostic factor. In contrast with what happens in undifferentiated NB, N-myc amplification does not have an adverse effect on prognosis when occurring in localized (stages I and II), stroma-rich NB with a favorable histology.

publication date

  • March 1, 1993

Research

keywords

  • Ganglioneuroma
  • Gene Amplification
  • Gene Expression Regulation, Neoplastic
  • Genes, myc
  • Neuroblastoma

Identity

Scopus Document Identifier

  • 0027534679

Digital Object Identifier (DOI)

  • 10.1016/0046-8177(93)90040-n

PubMed ID

  • 8454274

Additional Document Info

volume

  • 24

issue

  • 3