High-dose chemotherapy and autologous bone marrow support as consolidation after standard-dose adjuvant therapy for high-risk primary breast cancer. Academic Article uri icon

Overview

abstract

  • PURPOSE: We studied high-dose cyclophosphamide, cisplatin, and carmustine (CPA/cDDP/BCNU) with autologous bone marrow support (ABMS) as consolidation after standard-dose adjuvant chemotherapy treatment of primary breast cancer involving 10 or more axillary lymph nodes. PATIENTS AND METHODS: One hundred two women with stage IIA, IIB, IIIA, or IIIB breast cancer involving 10 or more lymph nodes at surgery were registered; 85 were eligible, treated, and assessable. Patients were treated with four cycles of standard-dose cyclophosphamide, doxorubicin, and fluorouracil (CAF), followed by high-dose CPA/cDDP/BCNU with ABMS. RESULTS: Actuarial event-free survival for the study patients at a median follow-up of 2.5 years is 72% (95% confidence interval, 56% to 82%). Comparison to three historical or concurrent Cancer and Leukemia Group B (CALGB) adjuvant chemotherapy trials selected for similar patients showed event-free survival at 2.5 years to be between 38% and 52%. Therapy-related mortality was 12%; pulmonary toxicity of variable severity occurred in 31% of patients. Quality-of-life evaluations indicate that patients are functioning well without major impairments. CONCLUSION: High-dose consolidation with CPA/cDDP/BCNU and ABMS after standard-dose CAF results in a decreased frequency of relapse in patients with high-risk primary breast cancer compared with historical series at the median follow-up of 2.5 years. Evaluation in a prospective, randomized trial is warranted and currently underway.

authors

  • Norton, Larry
  • Peters, W P
  • Ross, M
  • Vredenburgh, J J
  • Meisenberg, B
  • Marks, L B
  • Winer, E
  • Kurtzberg, J
  • Bast, R C
  • Jones, R
  • Shpall, E

publication date

  • June 1, 1993

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Bone Marrow Transplantation
  • Breast Neoplasms

Identity

Scopus Document Identifier

  • 0027191820

Digital Object Identifier (DOI)

  • 10.1200/JCO.1993.11.6.1132

PubMed ID

  • 8501500

Additional Document Info

volume

  • 11

issue

  • 6