Blunted serotonergic responsivity in depressed inpatients. Academic Article uri icon

Overview

abstract

  • We found a 38% lower maximal prolactin response to an oral challenge dose of 60 mg of dl-fenfluramine relative to placebo in younger (< 30 years) depressed inpatients compared with the response in age-matched healthy controls (p < .03). Severity of depression did not correlate with prolactin response. Prolactin responses in older depressed patients (> or = 30 years) did not differ from older controls. Younger depressed patients differed from older depressed patients in terms of earlier age of onset of first lifetime episode of major depression, greater degree of suicidal intent during a recent suicide attempt, double the level of hopelessness on admission to hospital, and a higher rate of comorbid borderline personality disorder. A blunted prolactin response to fenfluramine may be interpreted as evidence for reduced serotonergic function in younger depressed patients and may underlie their observed greater suicidality and hopelessness.

publication date

  • August 1, 1995

Research

keywords

  • Depression
  • Neurons
  • Serotonin

Identity

Scopus Document Identifier

  • 0029088295

Digital Object Identifier (DOI)

  • 10.1016/0893-133X(95)00016-7

PubMed ID

  • 8526971

Additional Document Info

volume

  • 13

issue

  • 1