Revised transthyretin Ile 122 allele frequency in African-Americans. Academic Article uri icon

Overview

abstract

  • The transthyretin (TTR) Ile 122 variant is associated with cardiac amyloidosis in individuals of African descent. To determine the prevalence of the allele encoding TTR Ile 122 in African-Americans, we have used PCR and restriction analysis to test DNA from African-Americans from various geographic areas, and found an allele frequency of 66/3376 (0.020), which is higher than the value we previously reported in a much smaller pilot study. Our data indicate that this TTR variant is present at equal frequency in African-Americans throughout the U.S., and suggest that this mutation may be a common, often unrecognized cause of cardiac disease in African-Americans.

publication date

  • August 1, 1996

Research

keywords

  • Black People
  • Prealbumin

Identity

Scopus Document Identifier

  • 0029946836

Digital Object Identifier (DOI)

  • 10.1007/s004390050199

PubMed ID

  • 8698351

Additional Document Info

volume

  • 98

issue

  • 2