Transcriptional regulation of the 5-HT2A receptor. Review uri icon

Overview

abstract

  • Complex transcriptional control mechanisms are responsible for the cell-type and antidepressant-induced regulation of the 5-HT2A receptor. Repressor domains in the 5' flanking region of the 5-HT2A receptor gene are the primary determinants to generate neuronal cell-specific transcription. Glial cell expression of the 5-HT2A receptor is achieved through a cell-type specific promoter activation. The downregulation of the 5-HT2A receptor by the atypical antidepressant mianserin is mediated by a drug response sequence in the 5' flanking region of the receptor gene.

publication date

  • January 1, 1996

Research

keywords

  • Antidepressive Agents
  • Receptors, Serotonin

Identity

Scopus Document Identifier

  • 0030030244

Digital Object Identifier (DOI)

  • 10.1016/0166-4328(96)00093-9

PubMed ID

  • 8788499

Additional Document Info

volume

  • 73

issue

  • 1-2