Interpersonal improvement in chronically depressed patients treated with desipramine. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: Interpersonal difficulties of dysthymic patients are little studied. We used the Inventory of Interpersonal Problems (IIP) to assess baseline status and medication response in chronic depression. METHOD: 39 chronically depressed subjects answered the IIP at entry and after 10 weeks of desipramine (DMI). Seventeen DMI responders completed IIPs after a 16-week continuation phase. RESULTS: Mean scores improved on all six IIP subscales during acute treatment. Continuation phase IIP improved non-significantly, approaching normative scores. Baseline IIP score correlated inversely with treatment outcome. CONCLUSIONS: Findings replicate in greater interpersonal detail research demonstrating rapid social amelioration in chronically depressed responders to antidepressant medication. The IIP may be useful as a predictive and interpersonal sensitivity measure in treatment studies of chronic depression.

publication date

  • November 4, 1996

Research

keywords

  • Antidepressive Agents
  • Depressive Disorder
  • Desipramine

Identity

Scopus Document Identifier

  • 0030569260

Digital Object Identifier (DOI)

  • 10.1016/0165-0327(96)00067-5

PubMed ID

  • 8938206

Additional Document Info

volume

  • 41

issue

  • 1