Blunted serotonin response to fenfluramine challenge in premenstrual dysphoric disorder. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: Indirect evidence suggests that abnormalities in serotonergic function may be involved in the pathogenesis of premenstrual dysphoric disorder. The goal of this study was to test the hypothesis of serotonergic deficiency in premenstrual dysphoric disorder by measuring the prolactin response to fenfluramine. METHOD: The authors administered the serotonin-releasing drug dl-fenfluramine in a placebo-controlled protocol to nine women with premenstrual dysphoric disorder and 11 healthy female volunteers in the luteal phase of the menstrual cycle. RESULTS: Compared to the normal subjects, the women with premenstrual dysphoric disorder had a significantly blunted prolactin response to fenfluramine. CONCLUSIONS: Premenstrual dysphoric disorder appears to be associated with serotonergic deficiency.

publication date

  • April 1, 1997

Research

keywords

  • Fenfluramine
  • Premenstrual Syndrome
  • Serotonin

Identity

Scopus Document Identifier

  • 0031005218

Digital Object Identifier (DOI)

  • 10.1176/ajp.154.4.556

PubMed ID

  • 9090347

Additional Document Info

volume

  • 154

issue

  • 4