Increased CSF glutamate following injection of ALS immunoglobulins. Academic Article uri icon

Overview

abstract

  • To reconcile the autoimmune and excitotoxic hypotheses regarding the etiology of amyotrophic lateral sclerosis (ALS), we injected rats intraperitoneally with ALS immunoglobulins and monitored CSF glutamate, aspartate, glutamine, and glutathione. CSF glutamate was significantly increased at 24 and 72 hours compared with both basal levels and disease control injected rats. CSF aspartate was increased at 72 hours. Glutamine and glutathione were unchanged. These data suggest that ALS immunoglobulins may enhance CSF glutamate and aspartate levels and contribute to motoneuron injury.

publication date

  • May 1, 1997

Research

keywords

  • Amyotrophic Lateral Sclerosis
  • Glutamic Acid
  • Immunoglobulins

Identity

Scopus Document Identifier

  • 0030911964

Digital Object Identifier (DOI)

  • 10.1212/wnl.48.5.1270

PubMed ID

  • 9153455

Additional Document Info

volume

  • 48

issue

  • 5