Kaposi's sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas. uri icon

Overview

abstract

  • This report describes two cases of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8)-associated lymphomas that primarily involved the large bowel and that secondarily caused malignant effusions. Involvement of the gastrointestinal tract is of interest because epidemiologic evidence suggests that KSHV/HHV-8 may be transmitted via the fecal-oral route, and KSHV/HHV8 DNA has been detected in rectal samples from HIV-positive patients. This report describes two HIV-positive men who developed primary KSHV/ HHV8-associated lymphomas of the bowel. Despite similar morphology and immunophenotype, these cases differ from most KSHV/HHV8-associated primary effusion lymphomas, which present with malignant effusions in the absence of a solid tumor mass. The spectrum of KSHV/HHV8-associated lymphomas is expanded to include a subset of primary bowel lymphomas in individuals infected with human immunodeficiency virus.

publication date

  • June 1, 1997

Research

keywords

  • AIDS-Related Opportunistic Infections
  • HIV Seropositivity
  • Herpesvirus 8, Human
  • Intestinal Mucosa
  • Lymphoma
  • Sarcoma, Kaposi

Identity

Scopus Document Identifier

  • 0031005354

Digital Object Identifier (DOI)

  • 10.1097/00000478-199706000-00013

PubMed ID

  • 9199651

Additional Document Info

volume

  • 21

issue

  • 6