Idiopathic thrombocytopenic purpura in a liver transplant recipient with previous primary biliary cirrhosis. uri icon

Overview

abstract

  • The loss of immunotolerance has been implicated in the pathogenesis of both primary biliary cirrhosis (PBC) and idiopathic, immune-mediated thrombocytopenic purpura (ITP). An association between these two autoimmune diseases has been well described. We describe a 41-year-old woman in whom ITP developed 457 days after liver transplantation for PBC while receiving immunosuppressive medications sufficient to maintain allograft function. Our case report, the first to describe post-transplant ITP in association with PBC, demonstrates the persistence of the underlying immune dysregulation of PBC after transplantation. The practice of decreasing the dosage of immunosuppressive medication to maintenance levels after transplantation may unmask the effects of this defect in immunotolerance.

publication date

  • June 1, 1997

Research

keywords

  • Immunosuppression Therapy
  • Liver Cirrhosis, Biliary
  • Liver Transplantation
  • Purpura, Thrombocytopenic, Idiopathic

Identity

Scopus Document Identifier

  • 0030797356

Digital Object Identifier (DOI)

  • 10.1097/00004836-199706000-00022

PubMed ID

  • 9252859

Additional Document Info

volume

  • 24

issue

  • 4